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Two studies using high throughput screening discovered active compounds with IC50 in the nanomolar range [78-79]

In one study called TIPO-1, participants were given different doses of tesofensine or a placebo along with a reduced-calorie diet for 24 weeks

If you find the 45 unit mark uncomfortably small to read, the honest options are (a) use a finer-gradation syringe, or (b) follow a protocol built around the 50 mg vial, whose larger draw is more forgiving not to freehand a bigger volume from the 10 mg vial, which would silently overdose relative to the documented figure

monitor patients for the emergence or worsening of depression, suicidal thoughts or behavior, and any unusual changes in moods or behaviors