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The precise origins of fibromyalgia remain elusive, but an intricate interplay of neurological, immunological, and genetic factors has been identified: Fibromyalgia patients exhibit heightened central nervous system sensitization, where normal sensory input is amplified into pain signals

Journal of cosmetic dermatology 2007

It can be combined with a mild scrub 1-2 times a week to enhance softening and brightening results without over-exfoliation

Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated