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Doses above 100mg daily show diminishing returns in NNMT inhibition the enzyme inhibition curve plateaus beyond 150mg while increasing the risk of methylation pathway disruption and homocysteine elevation

In this topic, we discuss some major symptoms that indicate deficiency of vitamin b12 in dogs

By inhibiting NNMT, the compound preserves the nicotinamide pool, allowing the salvage pathway to maintain higher NAD+ levels without external supplementation