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doi: 10.1016/j.neuron.2014.02.040 132 SquarzoniPOllerGHoeffelGPont-LezicaLRostaingPLowDet al

Daines SA

11% strongly disagree)

However, these results were insufficient to confirm the stability of ligandprotein binding and subsequent enzyme activation because docking deals with proteins as rigid molecules and ignore time evolution in ligandprotein interaction