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In recent years, percutaneous image-guided cryoablation (CA) has emerged as a promising option to treat soft-tissue lesions, particularly when conventional medical management is ineffective or not preferred by patients [8]

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Moreover, the number of amino acids contained in these disordered regions can be roughly estimated, enabling a semiquantitative, realistic description of the dynamic structure of IDPs (Kodera et al., 2021) Finally, an example of successful application of AFM for the characterization of IDP in the pre-IDP period is given by the 1997 report of H G