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GHK binds copper with exceptionally high affinity, forming a stable square-planar complex (GHK-Cu) that is the biologically active form responsible for the peptides regenerative effects

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Mechanistic studies have established that Dihexas procognitive and synaptogenic effects are mediated by the hepatocyte growth factor (HGF) / c-Met receptor system rather than by the classical AT 4 receptor, despite Dihexas structural origin as an angiotensin IV derivative

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