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2.5 Altered autophagy mechanism (and role of GBA1 gene) Autophagy is a process that in normal conditions maintains cellular balance by recycling proteins and organelles, and acts as an adaptive mechanism that helps cells survive under stressful conditions

Employing hepatocyte-specific genetic manipulation models and lineage tracing technologies to map the dynamic functional landscape of AhR during the progression of liver diseases will provide crucial insights into its role transition

Researchers should frame translational expectations accordingly rather than anchoring on the more favorable 12-week numbers