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Research has demonstrated that oridonin can decrease the nuclear Nrf2 levels by inhibiting JNK to enhance the effect of RAS-selective lethal 3 on accumulation of lipid peroxidation products and iron to induce ferroptosis in BC cells [189]

12 This hypothesis reframes the clinical distinction between RBD-PD and non-RBD-PD as potentially rooted in divergent pathogenic origins and provides a falsifiable biological framework for mechanistic investigation

We naturally produce glutathione, though factors like aging, stress, poor diet, and environmental toxins can deplete our glutathione levels over time

The role of toxins in chronic disease is an area of ongoing research, and while some studies suggest a connection, the evidence is not conclusive for all toxins and all diseases