cysteine converted to glutathione peroxidase Transsulfuration pathway activation attenuates oxidative stress and ferroptosis in sickle primary erythroblasts and transgenic mice Oncogenic accumulation of cysteine promotes

Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM

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1 Introduction Sepsis-associated encephalopathy (SAE) represents a severe complication of sepsis, defined by diffuse brain dysfunction without direct central nervous system (CNS) infection ( Oxidative stress is central to SAE pathogenesis, driven by an imbalance between excessive reactive oxygen species (ROS) production and impaired antioxidant defense systems ( The antioxidant defense system, especially GSH metabolism, is linked to neurodegenerative diseases ( Proteomics and metabolomics enable systematic profiling of protein expression and metabolic signatures

By modelling the BBB it is possible to make predictions about brain uptake of potential drug candidates and to study the effect of therapeutic interventions at the level of the cerebral capillaries