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Targeting CD38 suppresses induction and function of t regulatory cells to mitigate immunosuppression in multiple myeloma

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1 Introduction 1.1 Bile acids: key immuno-metabolic signals sculpted by the gut microbiota Bile acids (BAs), beyond their traditional role in lipid digestion, are now recognized as pleiotropic signaling molecules crucial for metabolic and immune homeostasis ( 1.2 The tumor immune microenvironment and dysregulation of the microbiota-bile acid axis in cancer Before delving into the pathological consequences of a dysregulated microbiota-BA axis, it is important to first establish its fundamental role in maintaining homeostasis

A., Moore, K