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These results suggest that POD and SOD are major contributors to antioxidant defense

144 ImberechtsD.KinnartI.WautersF.TerbeekJ.MandersL.WierdaK.et al (2022)

On the other hand, AGAT and GAMT deficient patients who have reduced ability for de novo synthesis of creatine, can be successfully treated with oral creatine supplementation, although very high doses of creatine are used, and the replenishment of cerebral creatine takes months (Ganesan et al., 1997)