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Mechanistically, PA disrupts intracellular iron homeostasis via ER calcium release, upregulates transferrin (TF)-mediated iron transport, and ultimately triggers ferroptotic death through iron overload ( 2.4 Induction of cell cycle arrest Cell cycle arrest, achieved by downregulating cyclins and cyclin-dependent kinases (CDKs), represents a key anti-cancer strategy

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Conversely, Mg deficiency enhances osteoclast and reduces osteoblast activity, decreases bone stiffness, weakens the apatite crystal structure, and interferes with vitamin D and parathyroid hormone (PTH) and, consequently, Ca homeostasis (60, 61)