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Nicotinamide N-methyltransferase (NNMT) is a key enzyme located in the cytosolic milieu that catalyzes the transfer of methyl group from the co-factor S-(5-Adenosyl)-L-methionine (SAM) to substrates such as nicotinamide (NCA), pyridine, and related analogs, such as quinoline, isoquinoline, and the1,2,3,4 tetrahydroisoquinoline.aliphatic amine NNMT directly regulates the detoxification of endogenous and exogenous drugs/xenobiotics by the formation of methylated metabolic products, such as 1-methyl nicotinamide (1-MNA), methylated pyridiniums, and methylated related analogs

Early symptoms of B12 deficiency: fatigue, numbness in extremities Remember also that PPIs if used for longer period of time reduces absorption of calcium supplements which is essential for bone formation and strength

Why Are Regular B12 Injections Important

These are real findings