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10.1016/j.neuint.2017.01.004 89 GuoJ.WangS.WanX.LiuX.WangZ.LiangC.et al

Istradefylline is an adenosine A2A receptor antagonist which was shown to reduce OFF-time ranging from 12 to 114 min in several trials and has been in clinical use to treat motor fluctuations in Japan for many years and more recently (2019) also received FDA approval [14, 146, 147]