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Consistent with the distribution of Firmicutes in the cecal samples, the relative abundance of Ileibacterium was highest in the WD controls (average relative abundance 68%), second highest in the LD controls (average relative abundance 51%), and lowest in the vehicle- and 5A-1MQ-treated mice switched from WD to LD (average relative abundances of 40% and 41%, respectively)

Others who may be more susceptible to vitamin B12 deficiency are patients diagnosed with Crohns disease or celiac disease, and those who have undergone intestinal procedures such as weight loss surgery

5-Amino-1MQ steps in as an NNMT inhibitor, effectively dialing down this enzymes activity

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