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The data on this is less clear

10.1016/j.reth.2022.10.008 206 WangG

PPAR- is majorly found in adipose tissues and modulates glucose metabolism, adipogenesis, and adipose tissue differentiation

On the other hand, successful treatment of an underlying deficiency, such as iron therapy for iron deficiency anemia, typically causes an elevated RDW to gradually decrease as new, more uniform red blood cells are produced