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This study suggests that AMPK has effects beyond autophagy, as it did not link the lifespan extension caused by GR with autophagy as previously indicated

Although both oxidized and antioxidant levels of lipids are higher in RA-FLS than in healthy controls, the increase in antioxidant levels is slightly higher than that of oxidation, indicating that RA-FLS is resistant to ferroptosis ( + T-cells from ferroptosis ( In studying TNF-, an important inflammatory mediator in the pathogenesis of RA, it was found that small doses of TNF- could enhance Cys uptake and GSH synthesis by activating the NF-B pathway

Schneich C, Asmus K-D, Dillinger U, and von Bruchhausen F (1989)

Although ferroptosis shows great potential in B cell immunomodulation and tumor therapy, the current treatment of DLBCL still faces significant challenges: the sensitivity of the GCB subtype to ferroptosis and the resistance of the ABC subtype create a therapeutic dilemma