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(2012) demonstrated: Statistically significant reductions in visceral adipose tissue of approximately 1518% over 26 weeks compared to placebo Meaningful increases in IGF-1 levels Improvements in triglyceride profiles in some patient subgroups Effects were partially reversed upon discontinuation, suggesting that sustained benefit requires ongoing therapy The consistency of the VAT reduction finding across multiple trials is what anchors tesamorelin's clinical utility

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AOD-9604 acts on adipocyte lipolysis pathways through beta-3 adrenergic receptor signalling, with effects measured at the fat cell level

Binding of mutants of human insulin-like growth factor II to insulin-like growth factor binding proteins 1-6