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575 In the SIRT3 knockout mouse model, the progression of fibrosis and cardiac hypertrophy also accelerated with age

Atlantic Ocean forcing of North American and European summer climate

These findings suggest that ApoJ contributes to disease progression not only by stabilizing amyloid fibril structures and accelerating plaque maturation but also by modulating post-translational modifications of tau protein, thereby exacerbating neuronal pathological damage [175]