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During phase I, the subjects begin forcefully exhalating against a closed airway, the intrathoracic pressure suddenly increases which leads to the brief increase in the systemic arterial blood pressure (ABP) and cerebral bloof flow

Target tissue concentration: SLU-PP-332's higher volume of distribution may result in better target tissue concentrations for certain applications

doi: 10.1016/J.REDOX.2025.103707 276 WuSFisher-HochSPReiningerBMLeeMMcCormickJB

However, its use is being explored as a potential treatment for a range of conditions including obesity, insulin resistance, metabolic syndrome, non-alcoholic fatty liver disease, fibromyalgia, ulcerative colitis, Crohns disease, functional constipation, IBS, and even cancer [153,154,155,156]