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Although our collective findings pointed at excess oxidative stress in the cytosol of parkin-deficient brain (herein), these unbiased proteomic screens had previously identified dysregulated cytosolic as well as mitochondrial enzymes without apparent difference in mitochondrial structures (or numbers) within neurons of the nigrostriatal pathway [22, 36]

Elevated TREM2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in Alzheimers disease models

Global and regional estimates of COPD prevalence: Systematic review and meta-analysis

Erqou S, Kaptoge S, Perry PL, Di Angelantonio E, Thompson A, White IR, Marcovina SM, Collins R, Thompson SG, Danesh J