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With regard to the increased secretion of EVs during the progression of NAFLD, experimental studies demonstrated that toxic lipids significantly increase the production of hepatocyte-derived EVs, which act as mediators of paracrine signaling, causing hepatic stellate cell activation, angiogenesis and activation of macrophages leading to inflammation and chemotaxis [103,104,105]

Intermittent fasting (e.g., 16:8 window) improves glucose regulation, blood pressure, and sleep if eating stops 3 hours before bed

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