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Methods Participants Patients aged 1855 with a diagnosis of schizophrenia or schizoaffective disorder were referred to the study by community-based mental healthcare teams in Nottinghamshire, Derbyshire and Lincolnshire, England (for inclusion and exclusion criteria, see SA1 (Supplement)

TABLE 2 Compound ( 10 ' 12 M) HGF Mimetic Activity N- heptanoyl-Tyr-Ile-(6) aminohexamide N- hexanoyl-Tyr-Ile-(6) aminohexamide ++++ N- pentaanoyl-Tyr-Ile-(6) aminohexamide _j N- butanoyl-Tyr-Ile-(6) aminohexamide +++ N- propananoyl-Tyr-Ile-(6) aminohexamide ++ N- acetanoyl-Tyr-Ile-(6) aminohexamide + N- benzoyl-Tyr-Ue-(6) aminohexamide + N- hexanoyl- (CH 2 -NIT 2 )-Tyr-Ile-(6) aminohexamide +++ Cell culture