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206 Several anecdotal reports, small case series, 194,209 and nonrandomized studies (primarily in HD patients with iron overload, elevated serum ferritin levels, and functional iron deficiency) using IV vitamin C in doses of 100 to 500 mg 3 times weekly have suggested a possible beneficial effect

Pain, burning, numbness, tingling, sensitivity to touch, red rash, blisters, and itching may occur

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Emerging solutions include encapsulating ferroptosis inhibitors in long-circulating liposomes or polymeric nanoparticles to prolong circulation and enhance myocardial deposition [376], as well as designing more stable analogues with improved pharmacokinetic profiles [375]