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doi: 10.4049/jimmunol.146.6.1914 204 McDowellA.BarnardE.LiuJ.LiH.PatrickS

Novel propargyl-linked bisubstrate analogues as tight-binding inhibitors for nicotinamide N -methyltransferase

This protein complex activates when monosodium urate (MSU) crystals meet macrophages in the body, which triggers the inflammation we see in gout flares [1]