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Results Godex improved insulin sensitivity and significantly decreased fasting plasma glucose, homeostatic model assessment for insulin resistance, steatosis, and gluconeogenesis, with a marked increase in fatty acid oxidation as well as better use of glucose in high-fat diet-fed mice

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Simultaneously, cachexia-induced metabolic reprogramming drives aberrant interorgan communication: the augmented Cori cycle exemplifies this cross-talk, where lactate shuttled from cachectic skeletal muscle to the liver fuels compensatory gluconeogenesis

The analysis of variance for repeated measures was performed to examine the interaction between the treatment and time