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For controlled trials, the comparator could include any non-drug intervention, such as behavioural interventions, placebo, or no support

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Thus, no single aggregate collection pathway appears essential for aggresome-like organelle formation, and multiple routes likely function in parallel for cargo delivery, consistent with adaptor requirements reported for mammalian models

I'd never heard of PA or B12 so after reading up I then find out that Heroin addicts get B12 deficiency so, I guess it was the Oxycontin that did cause it