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Furthermore, the presence of AHK-Cu may reduce the number of apoptotic DPCs, potentially increasing the Bcl-2/Bax ratio and lowering the levels of cleaved caspase-3 and PARP, two markers of cell death[2]

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Disclosure of interest: Mohamed Attia: nothing to disclose E-Posters - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.01 - PATHOPHYSIOLOGY OF STROKE / TRANSLATIONAL MEDICINE P2585 - ESOC25-1646 SEX DIFFERENCES IN WEIGHT LOSS AND ASSOCIATION WITH LESION VOLUME FOLLOWING INTRACEREBRAL HAEMORRHAGE IN THE RAT COLLAGENASE MODEL Jonas Vanderhaeghe 1 , Melissa Lajtos 1,2 , Luna Mestrum 1 , Mariska Meersschaut 1 , Robrecht Raedt 1 , Christian Vanhove 2 , Veerle De Herdt 1 1 4BRAIN, Ghent University, Ghent, Belgium, 2 IBiTech-MEDISIP-Infinity, Ghent University, Ghent, Belgium Background and Aims: Intracerebral haemorrhage (ICH) affects over 2 million people worldwide each year, resulting in substantial mortality and morbidity