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304,305 The procoagulatory state induced by sleep apnea may be a contributing factor in its association with an increased risk of heart attack and stroke

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The ability of hydroxocobalamin to rapidly scavenge and detoxify cyanide by chelation has resulted in several acute animal and human studies using systemic hydroxocobalamin doses at suprapharmacological doses as high as 140 mg/kg to support its use as an intravenous (IV) treatment for cyanide exposure