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doi: 10.1016/j.it.2011.03.007 27 MarshallESElshekihaHMHakimiMAFlynnRJ

Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity

Researchers have created carrier-free techniques, such as cross-linked enzyme aggregates (CLEAs) and crystals (CLECs), in response to the aforementioned problems [37]

Furthermore, TMAO promotes endoplasmic reticulum stress responses within podocyte cellular compartments via IRE1 and PERK pathway activation architectures, culminating in amplified production of inflammatory cytokine arsenals and accelerated apoptotic cell death trajectories (Pan et al., 2023)