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doi: 10.1056/NEJMoa1611925 212 MengZZhouDGaoYZengMWangW

This may potentially compromise mucosal protection and theoretically increase the risk of gastric irritation or ulceration

Moreover, astrocytes in AD often exhibit impaired phagocytic capacity and defective immune clearance, resulting in the accumulation of neuronal debris and secondary iron release, further exacerbating local cytotoxicity and iron dyshomeostasis (Zeng et al., 2025)

This process also disrupts vascular tone regulation, destabilizes hemodynamics, exacerbates blood pressure fluctuations and creates a vicious cycle that elevates the risk of cardiovascular events (159,160)