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The two methyl groups at the 3- and 5-positions fill a hydrophobic cleft that collapses in the absence of ligand, stabilizing the TM1-TM7 interface in the active conformation

doi: 10.1123/ijsnem.13.2.166

Despite numerous studies exploring the effects of Met supplementation in dairy and beef cattle, findings often vary, likely attributed to differences in experimental methodologies, RPM sources, and the developmental stages of the animals (Wei et al., 2022)