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doi: 10.1016/j.micpath.2023.106245, 34

The new regimen, which used half the dose of folinic acid of that used in the pilot study, resulted in significant increases in metabolites of the trans-sulphuration pathway as well as GSH:GSSG, although they remained below those of the control children

Reactivity, in biological systems, is almost inevitably associated with toxicity, and ROS can damage various biological molecules: lipids (causing lipid peroxidation and membrane damage), DNA (causing DNA breaks), and proteins (causing, for instance, oxidation of various amino acids and inactivation of essential enzymes)