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Ipamorelin (GHRP): Ipamorelin acts by mimicking ghrelin, binding directly to the ghrelin receptor (GHSR-1a)

The group of neurologists was also supported on certain arguments, such as physical activity, by external experts who were not involved in the final consensus

Prokinetic receptors 5-HT3 and 5-HT4, densely localized to myenteric plexuses and autonomic terminals, mediate distinct effects: 5-HT4 activation evokes acetylcholine release from cholinergic neurons, enhancing smooth muscle contraction (Pauwelyn and Lefebvre, 2017), whereas 5-HT3 sensitization of afferent nerves regulates motility rhythms and secretory (Touhara et al., 2025)