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Flora and Pachauri, 2010)

Fritz IB

Both HIF-1 subunits are basic helix-loop-helix PAS (an acronym for the first three family members, namely Per/ARNT/Sim) proteins: HIF-1 is a novel protein

3.3 Remodeling the TME Microbial metabolites orchestrate TME reprogramming through metabolic, epigenetic, and immune-stromal crosstalk, though their roles exhibit context-dependent duality requiring mechanistic prioritization