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: Direct stimulation of 1 -Adrenergic Activation 1 -adrenergic receptors on myocytes increases myocardial chronotropy (heart rate) and inotropy (contractile force), thereby elevating or maintaining cardiac output (CO), depending on the dose used (Solanki et al, 2014)

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Adiponectin downregulates CD163 whose cellular and soluble forms are elevated in obesity

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