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Blood 63 , 921926 (1984)

Also, phenytoin is an inducer of CYP450 isozymes, is metabolized by CYP450 enzymes, and is highly protein bound

Given that fMRI reactivity of the brain depends entirely on regional oxygenated hemoglobin levels, it is not completely clear whether the observed reductions in reactivity of in the brain are entirely due to underlying reductions in neural responses or at least partially due to decreased cerebrovascular responses