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CAR T-cell therapy involves collecting a patients T cells, genetically modifying them to express synthetic receptors (CARs) that recognize specific antigens, expanding them in the lab, and infusing them back into the body to find and destroy target cells (Figure 1)

The most common humanized mice include: SCID (severe combined immunodeficiency) mice and FRG ( FAH , fumaryl acetoacetate hydrolase, and RAG2 dual knockout) mice