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Results demonstrate that nanomolar concentrations of KPV inhibit NF-kappaB and MAP kinase inflammatory signaling pathways, leading to a reduction in pro-inflammatory cytokine secretion

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The mechanism is not entirely clear but it is hypothesized that the reduction in homocysteine from B vitamin supplementation may exert favorable and protective effects on nerve demyelination (31), and may attenuate the neurotoxic effects of homocysteine and N-methyl-D-aspartate (NMDA) agonists (32)