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This remarkable increase is, of course, out of all proportion to the increase of populationThis increasehas occurred, too, in Switzerland, Denmark, the U.S.A., Canada, and Australia, and has been reported from Turkey and Japan Many writers have studied these changes, considering whether they denote a real increase in the incidence of the disease or are due merely to improved standards of diagnosis

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Implications for Tobacco Harm Reduction Research While smoking remains one of the most important modifiable cardiovascular risk factors worldwide, the relationship between smoking status and hypertension is often complex and difficult to evaluate using cross-sectional population studies