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Beyond its proteolytic function, PR3 serves as the major autoantigen in anti-neutrophil cytoplasmic antibody-associated vasculitis, conferring special relevance in autoimmune diseases ( CatG exhibits distinctive dual biological characteristics, effectively degrading various extracellular matrix proteins while possessing significant antimicrobial activity

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Its journey from promising hGH fragment to discontinued candidate underscores the complexity of translating preclinical findings into safe, effective human therapeutics