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Along with iron chelators beneficial effects on ferroptosis, these results may indicate a potential capacity for metal chelators to improve efficacy and probably reduce required doses of tPA

In the Reactome Pathway analysis ( the present study found 'Metabolism of RNA', 'SUMOylation', 'SUMO E3 ligases SUMOylate target proteins', 'Interferon alpha/beta signaling', 'Mitochondrial translation' and 'Mitochondrial translation initiation' among the top five enrichment pathways ranked by P-value (Fig