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Treatment with high dose vitamin B12 been shown to be safe for more than 50 years Out of fear of overdosing vitamin B12, treatment is often reduced to below the frequency that is needed by the patient, or, even worse, treatment is stopped completely

however, because the former has proved as effective as the latter, DMF may be the only main active ingredient

Implementing strategies that targets the MGBA axis can significantly reduce RT-associated morbidities

Advances in proteomics and genomics have enabled the identification of novel drug targets, such as membrane proteins and enzymes essential for bacterial survival