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Researched For Glutathione serves as the principal intracellular redox buffer, and researchers use GSH/GSSG ratios as quantitative markers of oxidative stress in cell culture models, tissue samples, and animal studies investigating disease-relevant conditions

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Curr Alzheimer Res 10(2):174179 Wang R, Wang Y, Mu N, Lou X, Li W, Chen Y, Fan D, Tan H (2017) Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice

This reliance on correlative evidence from disease contexts has reduced CHAC enzymes to mere stress markers and overlooked their potential as dynamically regulated metabolic integrators