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For example, Taxol affects microtubule formation inside a cell, but a change in structure that increases intracellular activity may adversely affect the ability of Taxol to gain entry into a cell

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The Tpx1 cycle can be poisoned at high concentrations of peroxides through hyper-oxidation of the sulfenic acid form (SOH) to sulfinic acid (SO 2 H) [12, 13] (Fig