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For instance, in septic rats, mRNA levels of FoxO1 and FoxO3 in skeletal muscle remain elevated during the early stage, accompanied by sustained increases in MuRF1 and Atrogin-1 expression [198]

however, its role in mediating therapeutic resistance in non-small cell lung cancer (NSCLC) remains incompletely understood

All authors critically revised the manuscript and agree to be fully accountable for ensuring the integrity and accuracy of the work and read and approved the final manuscript

The epoxide is then activated by the hydrogen bond with the tyrosine residues and opened by a nucleophilic attack of the aspartate (which is orientated and activated by a histidine residue, a second carboxylic acid amino acid, and potentially other amino acids located in the catalytic center) on one of the epoxide carbons forming an enzyme-substrate ester intermediate