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Because it is a naturally occurring compound involved in energy metabolism, adverse effects are rare

Mazhar F, Krantz A, Schalin L, Lysell J, Carrero JJ (2023) Occurrence of adverse events associated with the initiation of methotrexate and biologics for the treatment of psoriasis in routine clinical practice

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The recombinant protein was recognized by known anti-P48/45 mAbs and induced antibodies with transmission-blocking activity in mice, suggesting it had adopted the correct conformation ( Chlamydomonas reinhardtii , a species of green algae, has been investigated as a low-cost option for production of vaccine candidate Pfs48/45