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One in vivo study assessed the effect of KD on the progression and metastatic development of cutaneous melanoma (222)

The authors explained that: "Although a greater number of dogs in the pimobendan group experienced spontaneous cardiac death (12 versus 5), the proportion of dogs in each group experiencing this event was not significantly different." They concluded: "Chronic oral administration of pimobendan to dogs with echocardiographic and radiographic evidence of cardiomegaly secondary to MMVD, in the absence of concurrent cardiovascular medication, results in the prolongation of the preclinical period, and is safe and well tolerated

Both of these agents feature improved dosing-frequency and AE profiles

Consequently, cutting down on these habits can often lead to a decrease in oral yeast infections