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As metabolites are the substrates used to generate chromatin modifications, including methylation and acetylation modifications of histones, a complicated interaction exists between metabolism and epigenetics

Diet induced obesity (DIO) model and vaccination To induce obesity and metabolic dysfunction, six-week-old male and female K18-hACE2 mice were provided a 60% fat diet (Research Diets #D12492) as replacement for standard mouse chow for a total of 21 weeks

Meanwhile, SAHA could block the compensatory upregulation of SCL7A11 induced by Erastin treatment alone and improve the efficacy of the drug [197]

Macrophage NCOR1 protects from atherosclerosis by repressing a pro-atherogenic PPAR signature