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Description

Irisin mitigates oxidative stress, chondrocyte dysfunction and osteoarthritis development through regulating mitochondrial integrity and autophagy

Therefore, our results, in both humans and rats, relating individual differences in accumbal GSH content to the capacity to succeed in task performance over time, supports the view that higher individual GSH levels provide an advantage to deal with oxidative processes generated by the drastically enhanced energy demand - involving increased O 2 utilization-required in NuAc circuits to maintain performance (see above)